Chemical Properties:

Palmitoylethanolamide (PEA) (CAS 544-31-0) is a white to off-white powder. PEA consists of palmitic acid and ethanolamine. It is the hydrolyzed form of N-(2-hydroxyethyl)-palmitamide, a crystalline structure isolated in soy lecithin. It is this hydrolyzed substance that accounts for the anti-inflammatory properties that were first noted by scientists in 1957. PEA's effects on the immune system have been studied since 1939.

Basic parameters:

Palmitoylethanolamide (PEA)   is a fatty acid amide molecule involved in a variety of cellular functions in chronic pain and inflammation. It has been shown to have neuroprotective, anti-inflammatory, anti-nociceptive (antipain) and anti-convulsant properties. Often in people with chronic disorders, the body does not produce enough PEA, which causes problems.

Taking PEA to supplement the body’s shortage is may be beneficial if you have chronic and neuropathic pain and inflammation, as has been demonstrated in clinical trials. These include peripheral neuropathies such as diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, sciatic pain, osteoarthritis, low-back pain, failed back surgery syndrome, dental pains, neuropathic pain in stroke and multiple sclerosis, chronic regional pain syndrome, chronic pelvic pain, postherpetic neuralgia, and vaginal pains.

Food Sources from Palmitoylethanolamide

Biological Activity:

Palmitoylethanolamide (PEA) is a natural fatty acid amide of ethanolamine and palmitic acid. It is found in soybeans, egg yolk, and many other food sources. PEA is an endogenous cannabinoid receptor agonist. It is a peroxisome proliferator-activated receptor α (PPAR-α) ligand. PEA possesses anti-inflammatory, anti-allergic, neuroprotective, and analgesic activities. It belongs to the class of lipid mediators and the N-acylethanolamine family. PEA blocks the release of pro-inflammatory mediators from activated mast cells and prevents the recruitment of activated mast cells at the site of nerve injury.

Mechanism of action of Palmitoylethanolamide

Palmitoylethanolamide works by affecting various receptors directly or indirectly, such as PPAR-a, CB1, CB2, GPR119, GPR55, etc.

Side effects:

There are no known problematic side-effects. PEA can be taken together with any other substance. It enhances the pain-relieving effect of classic analgesics and anti-inflammatories.

Palmitoylethanolamide can be used in combination with other substances without any side effects.

                      Palmitoylethanolamide(PEA) 's Uses and Benefits:

1) Pain management:

As a dietary supplement for reduce pain, PEA has analgesic (pain-relieving) properties and has been studied for its potential use in managing chronic pain conditions.

2) Anti-inflammatory effects:

PEA has been shown to have anti-inflammatory properties. It can inhibit the release of pro-inflammatory molecules and reduce the activation of immune cells involved in inflammation. PEA's anti-inflammatory effects may contribute to its analgesic properties.

3) Neuroprotective effects

: PEA has been investigated for its potential neuroprotective effects. It has been shown to protect neurons from damage caused by inflammation, oxidative stress, and other harmful processes. This suggests that PEA may have potential applications in neurodegenerative conditions and brain injuries.

4) Mood and anxiety modulation:

PEA has been studied for its potential effects on mood and anxiety disorders. It may exert its effects by influencing neurotransmitter systems involved in mood regulation, such as serotonin and dopamine pathways.

5) PEA is as a cosmetic powder.

Recently some studies show that PEA (CAS 544-31-0) powder can be used in cosmetics.

In the context of cosmetics, PEA is sometimes used as an ingredient due to its potential benefits.

6) Treating Alzheimer's disease and Parkinson's disease.

Palmitoylethanolamide(PEA)  powder could be make capsule,cream etc.

Below is some

Palmitoylethanolamide(PEA) brand on the market.

PEA capsule

PEA cream

PEA's  package:

25kg Fiber drum

FAQ:

1. What's MOQ for PEA and PEA ?

We have no limit for MOQ, We offer any quantity for customers.

2. How to buy PEA or PEA ?

You can click our website www.furtherpharma.com  or inquire by sending our mailbox:wuxifurther@gmail.com/ susie@further-pharm.com. 

3.How to guarantee the quality of PEA or PEA ?

We could offer you PEA's sample before you purchase large quantity.  

4.What's the package for PEA or PEA ?

1-2kg ziplock bag  3-25kg fiber drum

References:

1. Chemical book chemicalbook.com