Luteolin CAS 491-70-3 Dietary Flavonoid Antioxidant Anti-inflammatory Natural Plant extract Anticancer Inhibitors
Sources: Luteolin is a very typical kind of natural flavonoid and belongs to weak acidic tetrahydroxy flavonoids. It is widely distributed in the plant kingdom and is mainly presented in honeysuckle, chrysanthemum, Nepeta, Herba Ajuga and some other drugs as well as many kinds of vegetables such as thyme, Brussels sprouts, cabbage, cauliflower, beets, broccoli and carrots. Moreover, it is also distributed in the form of glycosides in celery, green pepper, and basil leaves as well as the fruit shell of the legume plant Arachis hypogaea, Ajuga decumbus, Lonicera japonica Thunb, Gentianaceae plant Gentianopsis paludosa, and Valerianaceae plant Valeriana amurensis Smir.
 

Molecular Formula:

Pharmaceutical effects:

1.Anti-tumor

: the inhibitory effect of luteolin on tumor cell proliferation is mainly through inhibiting certain intracellular kinase activity and causing cell cycle arrest.

2.Antioxidant

: the antioxidant effect of luteolin itself mainly exhibits as a reducing agent involved in the oxidation reaction as well as enhancing the activity of the biological antioxidant system.

3.Anti-inflammatory

: the anti-inflammatory activity of luteolin is mainly manifested that it can reduce the activity of inflammatory cytokine transcription factor and production of the pro-inflammatory cytokines and inflammatory mediators.

4.The neuro-protective effect

: luteolin has protective effect on the learning and memory ability of the nervous system.

5.Anti-fibrosis

: luteolin can reduce the extent of liver fibrosis, reduce the hydroxyproline (HYP) in the liver tissue, the content of malondialdehyde and the mRNA expression of type I pro-collagen mRNA. In vitro, it can inhibit the proliferation of hepatic star like cells (HSC) and collagen synthesis. It can also alleviate the bleomycin-induced pulmonary fibrosis and histopathological changes, reduce the lung weight index,  inhibit the expression of transforming growth factor-β1 (TGF-β1) mRNA in the lung tissue. In vitro, it can inhibit the proliferation of human embryo lung fibroblasts, induce the apoptosis.

6.Anti-fertility and hormonal effects

: luteolin has a significant dose-dependent anti-implantation activity. After oral administration, it can significantly increase the weight, diameter of uterine, the thickness of endometrium and the height of epithelial cells. Single administration has estrogenic effect while its combination with ethinyloestradiol exhibits anti-estrogenic effect.

7.Other functions

: luteolin can inhibit various kinds of bacteria and viruses, such as Staphylococcus aureus, Escherichia coli, herpes simplex virus, polio virus, Coxsackie B3 virus. It can inhibit the activity of integrase of AIDS virus HIV-1 and therefore has potential anti-HIV effect. Luteolin is able to bind to the s2 protein of the severe acute respiratory syndrome (SARS) corona virus, thus inhibiting viral for entry into host cells. Luteolin also has inhibitory effect on the Leishmania donovani. Through inhibiting the action of the topoisomerase I and topoisomerase II of Leishmania donovani and inhibit their growth. Additionally, luteolin also has immunomodulatory effects and so on.

Uses:

• to induce and elucidate the apoptotic pathway in renal cell carcinoma 786-O cell

• as an additive in M9 minimal medium to induce nodF gene expression

• as a reference standard to qualitatively and quantitatively analyse luteolin using reverse phase-high performance liquid chromatography with diode array detector (RP-HPLC-DAD)

• as a reaction supplement for β-galactosidase assay

• to elucidate the anti-inflammatory efficacy of luteolin in pseudorabies virus infected RAW264.7 cell line by measuring the anti-inflammatory mediators production and also cell viability and cytotoxicity assay

Storage:

Keep far away from fire and sunlight, dampness and keep in seal. 

Does your body need more Luteolin? When it needed Luteolin?

Your body will give indications and signs for you when it needed Luteolin.  

A poor neurological function that affects your motor skills, memory, or learning. This is more common in adults over the age of 50.

Development of wrinkles and visible signs. 

Luteolin is indicated in people dealing with inflammatory conditions like ​​gout, asthma, skin psoriasis, and erythema.

Recommended Dosage Of Luteolin

Now Luteolin supplements are still under research and are not recommended by the FDA for medical use.

Most luteolin supplements contain a mixture of luteolin and rutin (a flavonoid derived from quercetin).

The standard dosage mentioned on product labels ranges from 100-300 mg per serving.

Discussing the suitable dosage with your doctor before taking luteolin supplements is always recommended.

Possible Side Effects Of Luteolin Supplements

Though commonly eaten for its health benefits, the safety profile of luteolin is relatively unknown.

A few side effects reported with luteolin consumption include:

• Temporarily increased irritability in around 50% of children with autism spectrum disorders.

• Block the effects of progesterone, which may be harmful in women with uterine or cervical cancers.

• Worsens chemically-induced colitis in animal studies.

Food Sources From Luteolin

Foods that are rich in luteolin include

• Radicchio

• Celery

• Green bell peppers

• Citrus fruits

• Spices

• Herbs like thyme, basil, parsley, oregano, and chamomile tea

• Broccoli

• Cabbage

• Carrots

• Pumpkin

• Kohlrabi

FAQ:

1.  What's your MOQ for Luteolin?

We have no MOQ, any quantity is ok. We could meet customers' demand. 

2. What's your package of Luteolin?

We have two ways to pack. For 10~20kg, fiber drum, for 1-5kg, carton. 

3. Besides Luteolin, which dietary supplement has similar effects?

Palmitoylethanolamide also has effects for anti-inflammation, antioxidant etc.  In addition, Luteolin could be used with combination of Palmitoylethanolamide.

4. Could you offer sample of Luteolin?

Yes, we could offer sample for customers. 

References:

1. Chemicalbook     www.chemicalbook.com

2. Luteolin Supplements: Dosage, Usage, Benefits, And Side Effects   xcode.life